Gozzoli was from a farming family in Tuscany and moved to Florence as a child. He was taught painting in the workshops of the artist Fra Angelico, and assisted him with a number of major commissions including the Vatican Palace in Rome and Orvieto cathedral in Umbria.
As an artist in his own right, Gozzoli worked across Tuscany and Umbria and he was given prestigious commissions by the powerful ruling Medici family, including a wall painting series in their palace in Florence. His biggest commission was a series of 25 frescoes for the Campo Santo in Pisa, which took him 16 years to complete.
Gozzoli is not usually recognised as one of the foremost artists of the period, but he is celebrated for his use of bright colours and the liveliness of his backgrounds, or supporting figures and details in his works.